Graft Vs. Host Disease
Graft vs Host
Publication Date: 2006-07-26
Graft versus host disease is encountered among reciepients of bone marrow transplants performed for aplastic anemia, SCID, and leukemia. It may also occur with solid organ transplants, but is less common. Donor lymphoid cells trigger an immunologic reaction to the patient's skin, liver, lymphoid system, and GI tract. Symptoms develop in 30-90 days following the transplant and include a generalized skin rash, jaundice, and secretory diarrhea. Diffuse abnormalities of the small bowel develop with similar changes throughout the GI tract. There will be multiple fluid filled loops of large and small bowel with thickening and enhancement of the bowel wall. There may be similar enhancement of the gallbladder and urinary bladder walls. There may be infiltration of the mesenteric fat. The liver may be enlarged with periportal edema and possibly ascites.
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